Senior Scientist – Membrane Protein Biology

At Amgen if you feel like youre part of something bigger its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980 weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. Amgen is advancing a broad and deep pipeline and portfolio of medicines to treat heart disease obesity and obesity-related conditions rare diseases inflammatory conditions and cancer. As a member of the Amgen team youll help make a lasting impact on the lives of patients as we research manufacture and deliver innovative medicines to help people live longer fuller happier lives.

Our award-winning culture is collaborative innovative and science based. If you have a passion for challenges and the opportunities that lay within them youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist Membrane Protein Biology

What you will do

Lets do this. Lets change the world. Amgens Surfaceome Platform is advancing the discovery and validation of cell type-specific surface targets across multiple disease areas enabling the development of targeted therapeutics through a deeper understanding of cell-surface biology.

To support this mission the Surface Biology early validation group focuses on triaging proteomics- and transcriptomics-derived hits to define actionable target properties and guide early therapeutic modality selection. We are seeking a Senior Scientist with deep mechanistic expertise in membrane protein topology extracellular accessibility endocytosis receptor recycling and intracellular trafficking.

In this role you will develop hypothesis-driven experimental approaches to validate that candidate targets are presented on the cell surface and determine how their surface density localization intracellular trafficking and fate are regulated. These studies will generate robust quantitative decision packages to inform

Key Responsibilities:

• Validate cell-surface localization of novel target proteins across diverse cell models. Design optimize and execute quantitative approaches to measure surface target expression and investigate the mechanisms governing internalization endocytosis receptor recycling surface clearance and lysosomal degradation.

• Develop optimize and routinely execute fit-for-purpose cell-based functional assays to assess downstream biological consequences following genetic perturbation or treatment with tool compounds.

• Develop and experimentally test hypotheses about the mechanisms governing target protein localization and trafficking and their relationship to cellular function generating rigorous Go/No-Go decision packages to prioritize targets for modality selection and screening.

• Collaborate closely with colleagues within the early validation team and across functions to address evolving project needs rigorously document experimental workflows and present high-quality validated data in cross-functional team discussions.

What we expect of you

We are all different yet we all use our unique contributions to serve patients. The professional we seek is a collaborative critical-thinking scientist with these qualifications.

Basic Qualifications:

Doctorate degree (Ph.D.) and relevant post-doc experience where applicable

OR

Masters degree and 3 years of relevant scientific experience

OR

Bachelors degree and 5 years of relevant scientific experience

Preferred Qualifications:

• Ph.D. in Cell Biology Molecular Biology Biochemistry Pharmacology Bioengineering or a related biological discipline with 2 years of relevant postdoctoral and/or industry research experience.

• A strong record of independent hypothesis-driven research investigating the mechanisms governing membrane protein topology cell-surface accessibility endocytic trafficking or receptor recycling supported by rigorous experimental evidence and scientific publications.

• Demonstrated experience measuring surface target density endocytosis trafficking and turnover using cell-based quantitative readouts

• Strong hands-on expertise in real-time live-cell kinetic imaging systems and/or kinetic flow cytometry assays.

• Demonstrated experience working with microplate screening formats and scalable assay workflows with hands-on proficiency in designing troubleshooting and executing cell-based functional assays to evaluate the effects of membrane proteins on cellular functions.

• Strong data analysis skills problem-solving capability and clear scientific communication in multidisciplinary discovery teams.

• Experience designing and executing high-throughput cell-based screening assays.

As we work to develop treatments that take care of others we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills experience and qualifications.

In addition to the base salary Amgen offers a Total Rewards Plan based on eligibility comprising of health and welfare plans for staff and eligible dependents financial plans with opportunities to save towards retirement or other goals work/life balance and career development opportunities that may include:

• A comprehensive employee benefits package including a Retirement and Savings Plan with generous company contributions group medical dental and vision coverage life and disability insurance and flexible spending accounts
• A discretionary annual bonus program or for field sales representatives a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit you may redact or remove age-identifying information such as age date of birth or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Amgen anticipates accepting applications until 1 week after the posting; however we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates.

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world Amgen fosters an inclusive environment of ethical committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer. We make all employment decisions without regard to race color religion sex or any other characteristic protected by applicable law.

We provide reasonable accommodations to applicants and employees with disabilities consistent with legal requirements. Please contact us to request accommodation.

Salary Range