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Senior Scientist, Developability [Contract]
Job Location:
Job Location:
San Mateo, CA - USA
Monthly Salary:
Not provided by the employer
Monthly Salary:
Posted:
5 September 2026 (Yesterday)
Posted:
Application Deadline:
3 December 2026
Application Deadline:
Vacancies:
1 Vacancy
Vacancies:
Job Summary
The role: BigHat Biosciences is looking for a hands-on bench-driven scientist to perform IND-enabling developability assessments on late stage drug candidates from our Milliner Platform for AI-designed therapeutics. This is a lab-based 12-month contract role with the possibility but no guarantee of conversion to full-time position. Youll spend the majority of your time at the bench executing complex stability studies.
Key Responsibilities
- Lead design and execute in-use dose solution studies to assess drug compatibility with administration materials.
- Develop highly sensitive protein characterization methods (qSEC RP-HPLC CEX particle counting etc) for assessing drug quality and recovery.
- Support late-stage characterization including formulation screening stress testing and peptide mapping to rank and advance lead candidates.
- Drive developability assessments (purity stability tolerability biophysical properties) across programs with strong attention to data interpretation and organization.
- Communicate with and manage external CROs for testing and analytics.
- Interpret and communicate scientific findings propose next steps and broadcast clearly across the organization.
- Proactively identify and scope state-of-the-art analytical tools and developability technologies.
Skills Knowledge and Expertise
- PhD in Biochemistry or relevant discipline with 5 year(s) of industry experience; exceptional non-PhD candidates with deep bench experience will be considered.
- Experience developing and optimizing sensitive analytical chromatography-based methods is a must.
- Strong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC HIC CE-SDS DLS DSF ELISA LC-MS.
- Track record of translating complex data into clear results and recommended actions.
- Enthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality timelines throughput or cost.
Required Experience:
Senior IC
About Company
BigHat Biosciences designs safer, more effective biologic therapies for patients using machine learning and synthetic biology. BigHat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies. We apply these desig ... View more
