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Senior Bioinformatics Engineer
Job Location:
Job Location:
San Diego, CA - USA
Monthly Salary:
$ 129400 - 194000
Monthly Salary:
Posted:
16 May 2026 (30+ days ago)
Posted:
Application Deadline:
31 August 2026
Application Deadline:
Vacancies:
1 Vacancy
Vacancies:
Job Summary
What if the work you did every day could impact the lives of people you know Or all of humanityAt Illumina we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.Working at Illumina means being part of something bigger than yourself. Every person in every role has the opportunity to make a difference. Surrounded by extraordinary people inspiring leaders and world changing projects you will do more and become more than you ever thought possible.The estimated base salary range for the Senior Bioinformatics Engineer role based in the United States of America is: $129400 - $194000. Should the level or location of the role change during the hiring process the applicable base pay range may be updated accordingly. The range reflects longterm growth in the role; therefore most candidates are hired between the minimum and middle of the range. Placement depends on experience skills location and internal equity. Additionally all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work including access to genomics sequencing family planning health/dental/vision retirement benefits and paid time off.
We are a company deeply rooted in belonging promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation Illumina has always prioritized openness collaboration and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay regardless of gender ethnicity or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences increase cultural awareness and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex race creed color gender religion marital status domestic partner status age national origin or ancestry physical or mental disability medical condition sexual orientation pregnancy military or veteran status citizenship status and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local state and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local state and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process please contact To learn more visit: The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants.
Senior Bioinformatics Engineer Bioinformatics Platforms & Automation
Are you interested in building the bioinformatics platforms that power largescale genomic analysis At Illumina we are advancing genomics across research and clinical applications and we are seeking a Senior Bioinformatics Engineer to design build and operate backend bioinformatics systems supporting DRAGEN and related bioinformatics software.
This role is a handson development position focused on building bioinformatics automation QC systems and compute infrastructure that enable developers and scientists to move faster and with confidence. It combines bioinformatics expertise software engineering and systems ownership and directly supports some of Illuminas most businesscritical workflows.
Responsibilities
- Design develop and maintain backend bioinformatics platforms that support automated QC validation and largescale analysis workflows across the DRAGEN bioinformatics ecosystem.
- Build and evolve internal bioinformatics automation frameworks used for systemlevel validation regression testing and data quality assessment.
- Develop and maintain infrastructure components such as job orchestration queuing and scheduling systems used to manage DRAGEN compute workloads.
- Partner closely with software engineers bioinformatics developers and domain experts to define requirements and deliver robust scalable backend solutions.
- Design implement and improve bioinformatics algorithms and QC logic related to sequencing data processing.
- Provide operational ownership of bioinformatics compute environments including troubleshooting failures debugging system issues and improving reliability and observability.
- Enable and unblock developers by providing tooling infrastructure support and deep system knowledge across multiple teams.
- Leverage modern AIassisted development tools (e.g. intelligent code assistants workflow automation and agentbased tooling) to accelerate development debugging and system evolution.
- Establish and promote best practices for backend development bioinformatics automation testing and CI/CD.
- Participate in design reviews code reviews and crossfunctional technical discussions.
- Mentor junior engineers and contribute to a culture of technical excellence and continuous improvement.
Requirements
- Strong experience developing backend software in a highlevel language such as Python with solid software engineering fundamentals (data structures design patterns testing maintainability).
- Experience building or maintaining backend systems for data processing automation or infrastructureheavy workflows.
- Background in bioinformatics genomics molecular biology or a closely related computational field.
- Handson experience working in Linux environments including scripting and debugging distributed systems.
- Experience with job scheduling queuing systems or workflow orchestration (e.g. SLURM or similar concepts).
- Familiarity with CI/CD pipelines automation and production support practices.
- Experience using or interest in AIassisted software development tools to improve developer productivity and system quality.
- Ability to work independently manage ambiguity and own complex systems spanning software data and infrastructure.
- Strong communication skills and a collaborative serviceoriented mindset.
Preferred Qualifications
- Experience with NGS pipelines DRAGEN or largescale genomic data processing.
- Experience building internal platforms or developer tooling.
- Exposure to compute fleet operations onprem or hybrid infrastructure or regulated environments.
- Experience mentoring engineers or leading technical initiatives.
Education & Experience
- Typically requires a minimum of 5 years of related experience with a Bachelors degree; or 3 years and a Masters degree; or a PhD without experience; or equivalent work experience.
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We are a company deeply rooted in belonging promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation Illumina has always prioritized openness collaboration and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay regardless of gender ethnicity or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences increase cultural awareness and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex race creed color gender religion marital status domestic partner status age national origin or ancestry physical or mental disability medical condition sexual orientation pregnancy military or veteran status citizenship status and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local state and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local state and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process please contact To learn more visit: The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants.
Required Experience:
Senior IC
