Scientist II, Functional Bioassays & High Throughput Screening

The Role:

The Functional Bioassays team is seeking a Scientist II to develop optimize and execute functional assays across Generates therapeutic portfolio. This bench-focused role will generate high-quality data to guide protein design and program decisions including AI/ML-enabled design cycles.

The scientist will design optimize and troubleshoot biochemical and cell-based assays; execute high-throughput screening campaigns; analyze results; and support automation integration across programs. Work may include ion-channel GPCR ADC-related and other functional assay platforms as portfolio needs evolve.

Approximately 8090% of this role will be laboratory-based. The scientist will collaborate with colleagues across Therapeutics Technology and cross-functional program teams to deliver well-controlled data for iterative design-build-test-learn cycles.

This role is suited to a hands-on scientist with experience in functional assay development and high-throughput screening who can take ownership of experiments communicate results clearly and adapt to changing program needs.

Heres how you will contribute:

Design optimize and implement high-throughput screening-compatible cell-based and biochemical assays integrating automation where appropriate.

Plan and execute plate-based high-throughput screening campaigns analyze results and interpret experimental datasets.

Communicate findings to program teams to inform AI/ML-enabled design cycles program decisions and therapeutic optimization.

Support high-throughput functional assay work across multiple therapeutic programs with potential focus areas including ion channels GPCRs and ADC-related assays.

Apply and expand expertise in novel functional assay technologies including ion-channel and GPCR assays as program needs evolve.

Conduct experiments with attention to detail scientific rigor and adherence to established protocols.

Troubleshoot assay performance instrumentation reagents and workflows in partnership with senior scientists and Automation colleagues.

Maintain accurate timely and well-organized records in electronic laboratory notebooks and other data systems.

Prepare clear summaries of results for team discussions program updates and cross-functional meetings.

Coordinate experiments with colleagues across Functional Bioassays Automation Biology Protein Sciences Data Science and program teams.

Follow laboratory safety practices sample-handling requirements data-integrity expectations and Generates scientific standards.

The Ideal Candidate will have:

PhD in cell biology pharmacology immunology biochemistry bioengineering molecular biology or a related discipline with approximately 2 years of industry or postdoctoral experience; or MS with approximately 5 years of relevant industry or academic research experience; or BS with approximately 7 years of relevant industry or academic research experience.

Hands-on experience with cell-based biochemical and functional assays in an academic biotech pharmaceutical or related research setting.

Strong technical foundation in mammalian cell culture and plate-based assay workflows.

Experience with plate-based assay technologies such as ELISA HTRF AlphaLISA luminescence or fluorescence assays flow cytometry or similar methods.

Experience designing optimizing and executing high-throughput screening in 384- or 1536-well formats for small molecules biologics or both with appropriate controls and replicates sound data quality and clear documentation.

Ability to recognize assay-performance or data-quality issues investigate likely causes and contribute to troubleshooting.

Ability to work effectively in a fast-paced matrixed research environment where priorities may shift across programs.

Strong organizational skills and the ability to manage multiple experiments or workstreams.

Ability to analyze and present data at scale using tools such as Spotfire Dotmatics ScreenWorks Harmony iQue Forecyt or similar platforms.

Strong written and verbal communication skills including the ability to summarize results observations and next steps clearly.

Collaborative working style accountability curiosity and adaptability when learning new assay formats therapeutic areas and technologies.

Preferred Qualifications

Experience with ion-channel assays or related functional readouts such as patch clamp membrane-potential thallium-flux assays or electrophysiology workflows.

Experience with GPCR assays including reporter calcium-flux cAMP IP-one beta-arrestin or other pathway-based functional assays.

Experience with ADC image-based internalization targeted protein degradation immune-cell or cytotoxicity assay formats.

Experience with organoid-based screening workflows.

Experience working with primary cells engineered cell lines or stable cell-line generation.

Experience with laboratory automation systems such as HighRes Beckman Biomek i5/i7 Hamilton EL406 Multidrop or equivalent liquid-handling platforms.

Interest in applying functional biology to AI/ML-enabled therapeutic discovery.

Who Will Love This Job:

This is an opportunity to join Generates Functional Bioassays team at a time of significant portfolio growth. As a Scientist II you will play a hands-on role generating functional data that advances new therapeutic programs and supports rapid design-build-test-learn cycles. You will work on diverse biology learn new assay platforms collaborate across disciplines and build expertise in assay development high-throughput screening automation and drug discovery in a highly collaborative environment.

About Generate:Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creationone grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation this approach aims to reduce the uncertainty time and cost associated with developing protein-based medicines.

Founded in 2018 we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need faster guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race color ancestry religion sex national origin sexual orientation age citizenship marital status disability gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Companys internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

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