Research Scientist Electrophysiology Neurology

Site: The Brigham and Womens Hospital Inc.

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Job Summary

he Venkatesh Lab ( is seeking a highly motivated scientist to join our pioneering research efforts in the emerging field of cancer neuroscience. Our labs exciting new area of research lies at the intersection of cancer biology and neuroscience we focus on characterizing and therapeutically targeting electrical components of disease pathophysiologies. By improving our understanding of the cellular and molecular mechanisms involved in neuron-glioma communication and circuit formation in and outside of the brain the Venkatesh Lab aims to harness the systems level microenvironmental dependencies of tumor growth to develop innovative therapeutic treatments.

We are looking for an Electrophysiologist with a background in ex-vivo/in-slice electrophysiology and advanced microscopy strong organizational skills and the ability to attain a high degree of independence in a new and dynamic research this role the individual will conduct a variety of experiments including in slice and in vivo neuroimaging stereotactic surgeries and electrophysiology. As one of the first members of the Venkatesh lab team the candidate will also contribute to research work and publications on novel neuron-glioma circuit interactions using advanced neuroscience techniques.

Research Support 35%
Execute in slice and ex vivo patch clamp electrophysiology/optical recordings for ongoing projects within the lab.
Learn and alter techniques to patch clamp cancer cells as well as neurons.
Conduct microscopy imaging including confocal and 2-photon calcium imaging.
Perform mouse survival surgeries and post-op care for various projects and collaborations.
Provide basic assistance to researchers in computing and analyzing data using specialized statistical computer software.

Independent Research- 30%
Develop and explore independent projects within the field of cancer neuroscience under the direction of the PI.
Independently Review develop and implement new or modified laboratory techniques required for research projects.
Spearhead new projects and technique building in the lab.

Analysis- 25%
Publish scholarly reports and present at scientific conferences.
Build and utilize custom Python scripts (e.g. using pyABF Neo or Elephant) to automate the parsing feature extraction and kinetic analysis of intracellular voltage and current-clamp recordings.
Evaluate experiment results using statistical and multivariate analyses. Research compile and maintain complex statistical numerical and computerized reports.

Set up/Maintenance/Troubleshooting- 10%
Construct a complete electrophysiology rig setup to fit the needs of the lab/planned experiments.
Implement and develop in vitro electrophysiological protocols and assays to support multiple projects.
Schedule and maintain records of equipment/facilities. May assemble test calibrate clean or make minor repairs to equipment.
In addition to the above job responsibilities other duties may be assigned.

PhD Required. Ideally 3-5 years of previous experience in a research environment and 3 years experience with patch clamp.

• Experience with in vitro and ex-vivo patch clamp (cell lines primary neurons or slice electrophysiology).
• A strong understanding of microscopy (including brightfield confocal and 2-photon) digital-imaging platforms image quantification and interpretation is essential.
• Experience with other neuronal/glial function assays desirable. (eg. Ca2 imaging MEA)
• Expertise working with acute brain slice preparations and ideally primary neuronal cultures.
• In vivo recording experience a plus but not required.
• Proficiency in Python for electrophysiological data analysis including a strong grasp of scientific libraries (NumPy SciPy Pandas) and specialized ephys ecosystems for signal processing trace visualization and statistical modeling
  
  

The salary for this position ranges from $73544 to $81179.

IMPORTANT APPLICATION INSTRUCTIONS

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This position is being posted for informational purposes only. To be considered please submit the following directly to or by clicking the link below:

CV/resume

Cover letter

Contact information for three references

Onsite

60 Fenwood Road

2200 The Brigham and Womens Hospital Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religious creed national origin sex age gender identity disability sexual orientation military service genetic information and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973 the Vietnam Veterans Readjustment Act of 1974 and Title I of the Americans with Disabilities Act of 1990 applicants who require accommodation in the job application process may contact Human Resources at .