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Principal Statistical Programmer

Vertex Pharmaceuticals

Job Location:

Boston, NH - USA

Monthly Salary: $ 149200 - 223800

Posted: 31 May 2026 (30+ days ago)

Application Deadline: 28 August 2026

Vacancies: 1 Vacancy

Job Summary

Job Description

General Summary:

The Principal Statistical Programmer works with management to delegate tasks appropriately track progress and provide expert technical support to team addition the Principal Statistical Programmer is a designated member of clinical sub-team(s) in the role of project lead Statistical Programmer.

Key Duties and Responsibilities:

Works regularly with advanced features of SAS (including interfacing ability with other software applications and operating system tools)

Performs quality control checks of SAS code and output produced by other Statistical Programmers to ensure accuracy and consistency within group

Demonstrates in-depth knowledge of clinical development and medical data

Solves complex clinical trial reporting problems and demonstrates technical proficiency and exercises judgment in supporting daily operations and ensuring that study tasks are completed accurately and in a timely manner

Engages with a variety of other functions including Statistical Programmers Biostatisticians Data Management and other departments engaged in providing data and submission-related activities often at Senior Management levels

Creates all files documents and analyses necessary to support an electronic submission in eCTD format including ISS/ISE

Provides leadership to ensure compliance with Vertex SOPS and FDA/ICH/GCP regulations

Provides technical and project management skills to create review and approve documentation required to support data analysis reporting and CDlSC data submission

Participates in project management cross-functional teams that work on standard operating procedures guidelines process improvements system validation and acquisition customization and integration of new tools and technologies

Knowledge and Skills:

Proficiency in all SAS language procedures and functions commonly used in clinical trial reporting including the Macro language BASE SAS SAS/STAT and SAS/GRAPH

Intermediate knowledge of CDISC Standards

Intermediate knowledge of clinical trials

Regulatory submission experiences

Effective communication (written and verbal) skills to explain difficult information

Education and Experience:

Bachelors degree in a Scientific Discipline

Typically requires 5 for M.S. or above and 8 years for B.S. years of work experience in Biotech Pharmaceuticals or Clinical Research Organization

Pay Range:

$149200 - $223800

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors including skills competencies experience and other job-related factors permitted by law.

At Vertex our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career financial family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter) educational assistance programs including student loan repayment a generous commuting subsidy matching charitable donations 401(k) and so much more.

Flex Designation:

Remote-Eligible

Flex Eligibility Status:

In this Remote-Eligible role you can choose to be designated as:
1. Remote: work remotely five days per week and come into the office on occasion youre always welcome on-site; or select
2. Hybrid: work remotely up to two days per week; or select
3. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Remote

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at

Required Experience:

Staff IC

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