Principal Scientist, Protein Purification, Team Lead

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at .

As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biotherapeutics R&D

Job Category:

People Leader

All Job Posting Locations:

Spring House Pennsylvania United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at are searching for the best talent for Principal Scientist Protein Purification Team Lead in Spring House PA.

Purpose: At Johnson & Johnson Biologics Discovery we work in a fast-paced R&D environment applying rigorous scientific principles towards advancing groundbreaking protein support of this mission you will lead a team of scientists who deliver purified antibodies multispecifics and other therapeutic proteins for characterization and in vivo studies. Your group will combine purification science process development automation and protein biochemistry to generate preclinical candidates and drive decision-ready data.

As a partner across Discovery and Development you will connect biological activity manufacturability and program strategy. You will set direction build an inclusive and accountable culture and guide technical decisions that advance the strongest leads. You will lead and develop a protein purification team at the center of biologics discovery. We are seeking an exceptional scientific ideator and empathetic people leader who can identify bold practical solutions to discovery challenges turn large and complex datasets into insight and apply strong protein biochemistry expertise to advance therapeutic leads.

You will be responsible for:

• Build and develop the team. Coach scientists set clear expectations provide useful feedback and create an environment where people can grow raise risks and ideate.
• Drive lead-selection decisions. Partner with multidisciplinary project teams to define molecule-quality strategies interpret integrated data manage trade-offs and advance therapeutic leads.
• Set purification strategy. Guide fit-for-purpose purification and process development for antibodies multispecifics and other recombinant proteins including scalable handoff to development partners.
• Apply technical judgment. Use deep knowledge of chromatography FPLC HPLC protein quality and analytical methods to balance purity recovery speed scalability and downstream needs.
• Improve how the work is done. Advance automation digital tools and data workflows that strengthen throughput reproducibility and scientist experience.
• Deliver through partnership. Align priorities and communicate progress decisions and risks across expression protein engineering biophysics pharmacology and process development.

Qualifications/Requirements:

Required:

• PhD in biochemistry biochemical engineering chemical engineering protein science or a related discipline plus 5 years of pharmaceutical or biotechnology experience in biologics or drug discovery.
• Demonstrated experience leading and developing scientists and creating an inclusive collaborative high-accountability team.
• A drug-discovery orientation including sound judgment under uncertainty and experience using data to guide molecule or lead-candidate decisions.
• Deep expertise in purification and characterization of proteins antibodies or other biologics with hands-on experience in chromatography FPLC HPLC and relevant analytical methods.
• Experience originating or optimizing purification processes and transferring scalable approaches to development partners.
• Ability to influence across functions communicate complex science clearly and make timely decisions while inviting diverse perspectives.

Preferred:

• Bispecific or multispecific antibodies novel protein therapeutics complex molecular formats or antibody mechanisms of action.
• Discovery-to-development process transfer developability assessment early CMC partnership or manufacturability strategy.
• Laboratory automation high-throughput purification integrated data systems advanced analytics or responsible use of AI-enabled tools.
• Scientific publications patents external collaborations or other evidence of scientific curiosity initiative and impact.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource.

If you are under 18 years of age you (the candidate) may need to obtain the necessary working papers or other documentation required by state law to start the assignment as well as get a parents consent for the background check.

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Required Skills:

Preferred Skills:

Analytical Reasoning Biochemistry Chemistry Manufacturing and Control (CMC) Clinical Data Management Clinical Research and Regulations Clinical Trial Designs Developing Others Drug Discovery Development Inclusive Leadership Leadership Molecular Diagnostics Pharmacovigilance Process Improvements Productivity Planning Quality Assurance (QA) Scientific Research Team Management Technical Credibility