Principal Scientist, DMPK

Job Description

Our company is a global health care leader with a diversified portfolio of prescription medicines vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified itslegacy for over a century. Our company success is backed by ethical integrity forward momentum and an inspiring mission to achieve new milestones in global healthcare.

At our company we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve employee is building on our proudlegacy of scientific ability to impact the lives of patients worldwide depends on the integrity creativity humility and scientific acumen of our are creating a different organization that is inspired by invention and founded on a culture of respect and our company Research Labs (our Research & Development Division) Boston youll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

The Pharmacokinetics Dynamics Metabolism and Bioanalytics (PDMB) group is seeking a dynamic strategic thinking and collaborative Principal Scientist (director-level equivalent) to contribute to our company drug discovery and early clinical development efforts. This position will be based at our research labs in Boston MA. The ideal candidate will lead drug metabolism and pharmacokinetic (DMPK) efforts across multiple modalities such as peptides and protein therapeutics as a project-team representative regularly interacting with multi-disciplinary discovery teams and partners from other functions within our Research & Development Division. Therapeutic area support will focus on our immunology and oncology portfolios with the potential to contribute to cardiovascular/metabolic neuroscience and infectious disease efforts as well. The successful candidate will be expected to represent PDMB on cross-functional teams through strategic design of discovery testing funnels generation and interpretation of PK and PK/PD data sets and through effective communication at both internal meetings and external conferences.

In this exciting position your primary roles will include:

• Project-team representative and subject matter expert on multiple modality DMPK activities within the oncology and immunology therapeutic areas

• Characterization and optimization of the in vitro and in vivo ADME and pharmacokinetic properties of peptide and protein therapeutics

• Design implementation and analysis of in vitro and in vivo studies to understand the impact of drug disposition on disease biology pharmacological response (PK/PD) and safety

• Contribute to global DMPK strategy through close collaboration with Discovery and Early Development project teams in Boston (MA) South San Francisco (CA) and West Point (PA) focusing on building highly efficient strategies to identify and optimize drug candidates

Education Minimum Requirement

• Ph.D (with 6 years relevant experience) or Masters (minimum of 10 years relevant experience) degree in biochemistry chemistry pharmacology pharmaceutical sciences biomedical engineering or related field; Relevant experience to include a record of increasing responsibility and independence in a similar industrial/academic setting

Required Experience and Skills

• Demonstrated experience leading peptide and/or protein therapeutic (biologics) DMPK discovery efforts as an independent project-team representative within a highly collaborative environment

• Ability to design optimize and interpret DMPK-related optimization strategies (discovery testing funnels) as part of a broader research operating plan

• Technical ability to analyze interpret and provide context around data describing the ADME pharmacokinetic and pharmacodynamic properties including use of software such as Phoenix WinNonlin

• Experience contributing to development and execution of translational pharmacokinetic/pharmacodynamic/efficacy relationships and other useful quantitative pharmacology applications in a discovery setting

• Strong leadership interpersonal communication problem solving and collaborative qualities to deliver high quality results in a fast-paced environment

Preferred Experience and Skills

• Hands-on experience performing translational pharmacokinetic/pharmacodynamic/efficacy and physiologically-based pharmacokinetic (PBPK) software modeling (e.g. Phoenix WinNonlin Berkeley Madonna MATLAB).

• Proven track record supporting immunology or oncology-based programs with experience spanning from early discovery through IND-enabling efforts

• Familiarity with structure-activity relationships aimed at improving pharmacokinetic and pharmacodynamic properties

• Experience working within a research-driven pharmaceutical company

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The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive if applicable.

We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance

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