Principal Research Associate

Job Location:

Cambridge, MA - USA

Monthly Salary: $ 115000 - 135000

Posted on: 4 hours ago

Vacancies: 1 Vacancy

Job Summary

About Us

Deep Genomics is at the forefront of integrating artificial intelligence and complex biology to transform drug discovery. Our proprietary machine learning platform decodes the complexity of RNA biology to identify novel drug targets mechanisms and therapeutics inaccessible through traditional methods. With expertise spanning machine learning drug development bioinformatics data science genetics and chemistry our multidisciplinary team in Toronto and Cambridge MA is revolutionizing how medicines are created.

About the role

The Principal Research Associate will join our Platform Biology team and will be a key player in driving our cutting-edge AI RNA therapeutics discovery this role you will be responsible for helping characterize our novel compounds including performing automated high-throughput arrayed screening as well as downstream characterization of these molecules. Further you will be instrumental in helping develop optimise and implement novel cellular and protein assays to advance our internal therapeutics portfolio. The ideal candidate will have strong cell biology expertise and hands-on experience using primary hepatocyte cells. Relevant knowledge of RNA modalities such as ADAR ASO mRNA and/or siRNAs is also highly beneficial. The successful candidate should demonstrate initiative technical ownership and be able to thrive in a dynamic work environment with cross-functional teams working together to achieve company goals.

This position is onsite at our Cambridge MA site.

Key Responsibilities

Design optimise and execute robust cell-based assays to support compound screens and lead optimisation.
Culture maintain and transfect a variety of mammalian cell lines such as immortalized cell lines primary cells and co-culture systems and onboard new cell types and systems to enable drug discovery.
Examine important molecular and functional endpoints in vitro including RNA and protein readouts to better understand our molecules in our internal therapeutic pipeline.
Perform standard molecular biology techniques (e.g. PCR qPCR Jess/Leo Automated Westerns ELISA Western blot etc.).
Collaborate with a cross-functional team in a dynamic matrixed environment to achieve shared company deadlines and communicate experimental design and findings with colleagues and project teams.
Clearly document experiments standard operating procedures (SOPs) and data in an electronic lab notebook (ELN).

Basic Qualifications

BS or MS in Biology Molecular Biology Genomics Biochemistry or a related field with 4 years of relevant pharmaceutical or biotechnology experience.
Strong hands-on experience growing maintaining and transfecting mammalian cell lines.
Good understanding of molecular and cell biology.
Experienced in design and execution of molecular and cellular assays including documentation in an electronic lab notebook (ELN).
Excellent communication organizational skills and a willingness to learn.
Ability to prioritise and drive work independently in a fast-paced technical and data-rich environment.

Preferred Qualifications

Hands-on experience using primary hepatocytes is strongly preferred.
Proficiency in automated Western blotting methods such as the Jess/Leo platforms.
Flow cytometric experience is a plus.
Experience with high-throughput liquid handlers (e.g. Beckman Echo Agilent Bravo and/or Hamilton STAR/STAR V).
Next-generation sequencing library preparation e.g. amplicon sequencing.
Past experience with RNA editing and/or RNA oligonucleotides.
Demonstrated experience working in cross-functional teams.

What We Offer

A collaborative and innovative environment at the frontier of computational biology machine learning and drug discovery.
Highly competitive compensation including meaningful stock ownership.
Comprehensive benefits - including health vision and dental coverage for employees and families employee and family assistance program.
Flexible work environment - including flexible hours extended long weekends holiday shutdown unlimited personal days.
Maternity and parental leave top-up coverage as well as new parent paid time off.
Focus on learning and growth for all employees - learning and development budget & lunch and learns.
Facilities located in the heart of Toronto - the epicenter of machine learning and AI research and development and in Kendall Square Cambridge Mass. - a global center of biotechnology and life sciences.

Deep Genomics encourages applications from all backgrounds who seek the opportunity to build the worlds leading AI-driven genetic medicine company.

If you have a disability or special need accommodation is available on request for candidates taking part in all aspects of the selection process.

*This posting reflects a current vacancy.

We offer competitive compensation aligned with local market benchmarks. The salary range for this role is $115000 - 135000 and reflects Cambridge USA-based roles.

We may use artificial intelligence (AI) tools to support parts of the hiring process such as reviewing applications analyzing resumes or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed please contact us.

Required Experience:

Staff IC

About UsDeep Genomics is at the forefront of integrating artificial intelligence and complex biology to transform drug discovery. Our proprietary machine learning platform decodes the complexity of RNA biology to identify novel drug targets mechanisms and therapeutics inaccessible through traditiona...