Principal Bioinformatician

Legend Biotech is a global biotechnology company dedicated to treating and one day curing life-threatening diseases. Headquartered in Bridgewater New Jersey we are advancing the next generation of cell therapy through a portfolio of innovative technologies including autologous allogeneic and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T) T-cell receptor (TCR-T) natural killer (NK) cell-based therapies and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites we are committed to discovering and developing safe effective and cutting-edge therapies for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.

Legend Biotech is seeking a Principal Bioinformatician as part of the Early Drug Development team based in Somerset NJ or Remotely.

Role Overview

This role is to support translational strategies across pipeline development programs. He/She will lead computational analyses integrating multi-modality clinical and biomarker datasets to enable mechanism-of-action understanding patient stratification pharmacodynamic assessment etc. to support translational decision-making.

Key Responsibilities

• Translational Biomarker Analysis with multi-modality and multi-omics assays such as Bulk and Single cell RNA-seq TCR/BCR-seq WGS/WES Amplicon-seq ATAC-seq ctDNA/liquid biopsy Proteomics and cytokine profiling spatial and multiplex imaging Flow cytometry/CyTOF.
• Support translational biomarker discovery and validation including identification of pharmacodynamic (PD) predictive prognostic and response biomarkers; integrated analyses correlating biomarker data with: Clinical outcomes PK/PD measurements Safety for Patient stratification and Mechanism-of-action hypotheses.
• Build and maintain reproducible and scalable bioinformatics pipelines using cloud or high-performance computing environments. Contribute to translational data infrastructure and data governance strategies. Ensure analysis reproducibility traceability and documentation compliance. Ensure analysis reproducibility traceability and documentation compliance.
• Partner closely with Translational scientists Clinical Development Research and CMC teams CROs and collaborators to help translate complex computational findings into biologically meaningful insights.
• Contribute to regulatory documentation required biomarker sections of INDs IBs Clinical study reports and Regulatory briefing documents.
• He/she has the authority to make decisions related to methodologies and approaches development can make decisions related to project execution including timelines milestones and resource allocation within budget. Higher-level approvals are required for those related to significant technical selection budget allocations strategic shifts or major collaborations that have substantial scientific financial or long-term implications.

Requirements

• PhD (5 years) or MS (8 years) in Bioinformatics Computational Biology Genomics Systems Biology and related quantitative biological sciences.
• Strong expertise in bioinformatics statistics with some biological training background with experience in translational research in oncology immunology or autoimmune disease. Gene and cell therapy involvement is a plus.
• Strong experience with: R and/or Python programming Linux/Unix computing environments Workflow management systems (e.g. Snakemake Nextflow WDL) with Cloud platforms (AWS GCP Azure) preferred

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Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

Work Authorization & Employment Eligibility

Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations we participate in the E-Verify program. If you are selected for employment you will be required to complete the Form I-9 process and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair transparent and welcoming hiring experience for all candidates.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race color creed religion national origin ancestry citizenship status age sex or gender (including pregnancy childbirth related medical conditions and lactation) gender identity or gender expression (including transgender status) sexual orientation marital status military service and veteran status disability genetic information or any other protected characteristic under applicable federal state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.