Jr. Scientist IIX-Ray Crystallographer

Odyssey is looking for a Jr. Scientist II Xray Crystallography to join a dynamic and growing team at the Walter Reed Army Institute of Research (WRAIR) Wound Infection Department (WID). WID is tasked with delivering specific effective countermeasures for infection of combat wounds pre-injury at the point-of-injury and post-injury. The Structural Biology (XTAL) group focuses on structure-based drug designs for microbial pathogens of military relevance. Researchers in this group express purify and crystallize ESKAPEE pathogen proteins of interest and utilize sophisticated techniques such as X-ray Crystallography and Mass Spectroscopy to model small molecule drug-protein interactions.

Duties include but not limited to:

• Be familiar with the fields concepts practices and procedures including but not limited to microbiology immunology vaccinology biochemistry genetics molecular biology clinical trials and bioinformatics.
• Work independently and as part of a scientific team to understand and resolve complex biological questions while contributing to product development through the analysis and interpretation of data presentation of data at meetings the establishment of collaborations both internal and external to WRAIR and the solicitation of grants and the writing of successful proposals.
• Actively pursue the scientific objectives of the Branch and contribute significantly to the critical strategic planning and execution of future studies.
• Design develop and deliver novel small molecule antibiotics against MDR organisms of military relevance through structure-based drug design.
• Identify novel small-molecule drug candidates through in silico screening of commercially available chemical databases and molecular modeling of drug candidates for enhancement.
• Express purify and crystallize proteins for structure-based drug design and perform mass spectrometry on all products.
• Develop and recommend antimicrobial drug candidates for specific targets on MDR ESKAPEE pathogens (Enterococcus species Staphylococcus aureus Klebsiella pneumoniae Acinetobacter baumannii Pseudomonas aeruginosa Enterobacter cloacae and Escherichia coli).
• Draft grant proposals on structure-based drug design for submission to leadership and research steering committees.
• Conduct research on projects associated with antimicrobial development such as protein expression and purification MIC (minimum inhibitory concentration) studies animal modeling virtual modeling of drugs bound to target proteins etc.
• Independently design experiments make detailed observations analyze data interpret results and deliver timely results.
• Mentor and supervise junior scientists within the team as needed.

Minimum Required Qualifications:

Citizenship: Must be a US citizen or Green Card holder and lived in the U.S. three out of the last five years

Clearance: Ability to Obtain NACI

Education: Ph.D. in an appropriate discipline (e.g. microbiology immunology Molecular Biology or biochemistry)

Years of Experience: At least three (3) years of experience in protein characterization and chemistry

Preferred Qualifications:

Clearance: NACI

Education: Ph.D. in an appropriate discipline (e.g. microbiology immunology Molecular Biology or biochemistry)

Years of experience: 3-5 years of experience in protein characterization and chemistry

Technical Skills

• Experience and training using BRUKER X-Ray Diffractometers.
• Experience in at least one of the following areas: druggable target identification cloning enzymology protein characterization and protein chemistry.
• Strong computer skills and experience with relevant software including MS Office and GraphPad Prism.
• Experience with microbiology of Gram-negative negative species and antibacterial development is desired.
• Must have a proven track record of securing competitive grant funding.
• Must have excellent presentation and oral and written communication skills.
• Ability to prioritize and work in a fast-paced and diverse environment. Contribute individually as well as part of a highly collaborative and productive team.
• Must have proven ability to prepare precise technical summaries and protocols and maintain appropriate documentation.

Interpersonal Skills

• Teamwork
• Problem-Solving
• Critical Thinking
• Communication
• Attention to Detail

Additional Information

Location: Walter Reed Army Institute of Research (Silver Spring MD)

Travel: 5%

Remote Onsite or Hybrid: Onsite

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Odyssey is a world-class technical engineering and integration company serving the warfighting ecosystem with airborne integration ISR C2 and warfighter readiness capabilities. Odyssey meets the militarys operational needs by integrating layered defense systems from equipment technology and services to data information and business operations. We streamline defense acquisition and sustainment engineering the technical battlefield with domain-specific proficiency to ensure lethality. Odyssey is dedicated to excellent contract execution peak organizational performance and fostering a workplace built on employee care.

Odyssey is proud to live out our core values of commitment ambition and respect in our work and communities through OdysseyCares a philanthropic group focused on giving back through direct donations an employer match program and volunteering events.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Final compensation for this position will be determined by various factors such as the Federal Government contract labor categories and contract wage rates relevant work experience specific skills and competencies geographic location education and certifications.

This position is filled through continuous recruitment and will remain open until a sufficient pool of applications has been received.

Hired applicants may be eligible for benefits including but not limited to medical dental vision life insurance Tricare supplement short-term disability long-term disability 401(k) match flexible spending accounts health savings accounts employee assistance program learning and development benefit paid time off and holidays.

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