Data Scientist, Department of Internal Medicine (Phoenix)

The University of Arizona College of Medicine Phoenix seeks a highly motivated Research Data Scientist to support cutting-edge biomedical research focused on genomics single-cell biology and spatial transcriptomics in the Wondisford Laboratory Department of Internal Medicine. The successful candidate will work with faculty investigators including members of Dr. Wondisfords laboratory and Dr. Shenfeng Qiu Director of Spatial Transcriptomics Core Facility to analyze and interpret large-scale multi-omics datasets generated from diverse biological systems and disease position will play a critical role in advancing research projects involving single-cell RNA sequencing (scRNA-seq) single-nucleus RNA sequencing (snRNA-seq) spatial transcriptomics and related genomic technologies. The candidate will develop and implement computational workflows for data processing quality control cell type annotation differential expression analysis integration of multimodal datasets machine learning applications visualization and biological interpretation.

The successful candidate will collaborate closely with investigators throughout the research lifecycle from experimental design and sample processing through data analysis figure generation manuscript preparation and grant development. While the primary focus is computational analysis opportunities may exist to participate in wet-lab activities related to tissue collection sample preparation library construction spatial transcriptomics workflows and coordination of sample submission to external sequencing facilities. The candidate will work in a highly collaborative and interdisciplinary research environment utilizing state-of-the-art single-cell and spatial transcriptomics platforms including 10x Genomics Chromium Visium Visium HD and Xenium technologies.

Visa sponsorship is not available for this positions.

Outstanding U of A benefits include health dental and vision insurance plans; life insurance and disability programs; paid vacation sick leave and holidays; U of A/ASU/NAU tuition reduction for the employee and qualified family members; retirement plans; access to U of A recreation and cultural activities; and more! The University of Arizona has been recognized for our innovative work-life programs. For more information about working at the University of Arizona and relocations services please click here.

• Develop maintain and optimize computational pipelines for analysis of single-cell RNA sequencing single-nucleus RNA sequencing and spatial transcriptomics datasets.
• Process and analyze large-scale genomic datasets generated from 10x Genomics Chromium Visium Visium HD Xenium and related platforms.
• Perform quality control clustering cell type annotation differential gene expression analysis trajectory analysis data integration and multimodal analyses.
• Apply machine learning statistical and bioinformatics approaches to identify biologically meaningful patterns and generate testable hypotheses.
• Develop reproducible analysis workflows using Linux-based computing environments high-performance computing resources and version-controlled code repositories.
• Generate publication-quality figures visualizations summaries and reports for manuscripts grant applications presentations and progress reports.
• Work directly with faculty investigators to interpret results troubleshoot analyses and develop data-driven research strategies.
• Assist with management organization storage and archival of large genomic datasets.
• Collaborate with laboratory personnel regarding experimental design sample preparation sequencing strategies and downstream analyses.
• Coordinate data transfer sequencing submissions sample tracking and communication with sequencing and genomics service providers.
• Contribute to preparation of manuscripts abstracts presentations and extramural grant applications.
• Train students staff and investigators in computational analysis methods and best practices for genomic data analysis.
• Participate in laboratory meetings research seminars and collaborative project discussions.
• May assist with tissue collection sample preparation library construction spatial transcriptomics workflows and related laboratory activities as needed.

Knowledge Skills and Abilities:

• Strong computational and analytical skills with demonstrated experience in biological genomic transcriptomic or other large-scale scientific data analysis.
• Proficiency in Linux/Unix operating systems and command-line environments.
• Experience with Bash scripting and workflow automation.
• Proficiency in R and/or Python programming for scientific computing and data visualization.
• Experience with commonly used single-cell and spatial transcriptomics software packages.
• Knowledge of machine learning statistical analysis dimensionality reduction clustering methods data visualization techniques and biological data integration approaches.
• Ability to communicate complex computational findings to investigators with diverse scientific backgrounds and work effectively in a collaborative multidisciplinary research environment.
• Ability to manage multiple collaborative projects simultaneously while meeting deadlines.
• Strong organizational skills attention to detail excellent written and verbal communication skills.

This job posting reflects the general nature and level of work expected of the selected candidate(s). It is not intended to be an exhaustive list of all duties and responsibilities. The institution reserves the right to amend or update this description as organizational priorities and institutional needs evolve.

• Masters degree or equivalent advanced learning attained through professional level experience required.
• Minimum of 5 years of relevant work experience or equivalent combination of education and work experience.

• Bachelors degree Masters degree and/or Ph.D. in Bioinformatics Computational Biology Genomics Biomedical Informatics Computer Science Statistics Systems Biology Neuroscience Biomedical Sciences or a related field.
• Experience analyzing single-cell RNA sequencing and/or single-nucleus RNA sequencing datasets.
• Experience analyzing spatial transcriptomics datasets generated using 10x Genomics Visium Visium HD Xenium MERFISH CosMx or related platforms.
• Experience using Seurat Scanpy scvi-tools CellChat Monocle Harmony Azimuth SingleR or related software packages.
• Experience with machine learning deep learning artificial intelligence or multimodal data integration methods.
Experience utilizing high-performance computing clusters and cloud-based computing environments.
• Familiarity with wet-laboratory techniques related to genomics next-generation sequencing single-cell technologies or spatial transcriptomics.
• Experience contributing to peer-reviewed publications grant applications and collaborative research projects.
• Experience developing reproducible computational workflows and software tools for biological data analysis.

Office of Human Resources Talent Acquisition

Application: The online application should be completed in its entirety. Blank or missed information may be considered an incomplete submission.

Cover Letter: Should clearly indicate how your skills and professional employment experience meet the Minimum and the Preferred qualifications (if applicable).