Biologist

Job Family:

Travel Required:

Clearance Required:

What You Will Do:

We are looking for a Biologist to support drug repurposing screening projects disease model development assay development and scientific research activities for the National Center for Advancing Translational Sciences (NCATS). This is a full-time position located in Rockville MD.

• Work with assay providers for assay development and assay transfer to the TDB program.

• Perform assay development optimization and miniaturization activities.

• Conduct high throughput screening using known drugs and bioactive compounds to identify active compounds.

• Confirm primary hits and perform secondary and tertiary assays to narrow candidates to top lead compounds.

• Perform mechanistic studies to characterize lead compounds when necessary.

• Evaluate and apply new technologies and instruments to establish physiologically relevant disease models.

• Characterize human induced pluripotent stem cells (iPSCs) and iPSC-derived cells including developmental marker analysis and disease phenotype studies.

• Establish human iPSC-derived cell-based assays for disease modeling.

• Lead assay development and compound screening using high-content imaging and flow cytometry assays.

• Operate and maintain high throughput flow cytometry instrumentation including the iQue flow cytometer.

• Maintain accurate scientific records and communicate effectively with collaborators and project teams.

• Present research findings at internal and external scientific meetings.

• Write submit and support the publication of scientific manuscripts.

• Assist team members with manuscript preparation and revisions.

• Collaborate with staff scientists postdoctoral fellows IRTA fellows and external collaborators.

• Mentor and train postbaccalaureate IRTA fellows and summer students.

• Support the overall operational and scientific objectives of NCATS research programs.

• Incumbent capture no other candidates were considered due to incumbent candidate identified. They meet the labor category requirements provided by the customer

What You Will Need:

• Ph.D. in Molecular Cell Biology or Biological Sciences.

• Minimum of EIGHT (8) years of experience in flow cytometry assays.

• Experience in assay development high-content imaging assay analysis compound screening and lead identification.

• Experience with in vitro and in vivo disease model systems.

• Proficiency with FlowJo GraphPad Prism and Microsoft Office.

• Strong oral and written communication skills.

• Demonstrated ability to write scientific manuscripts and present scientific data and research findings.

• Ability to maintain accurate laboratory documentation and records.

• Must be able to obtain and maintain a Federal or DoD public trust; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

What Would Be Nice To Have:

• Background supporting drug repurposing programs.

• Ability to work independently and collaboratively in a multidisciplinary research environment.

• Hands-on use of high throughput screening platforms and technologies.

• Ability to establish disease models using human primary cells or iPSC-derived cells.

• Skilled in mentoring junior researchers fellows and students.

• Collaborative approach with external scientific partners and multidisciplinary project teams.

• Scientific publication record in peer-reviewed journals.

• Track record presenting research at national or international scientific conferences.

What We Offer:

Guidehouse offers a comprehensive total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical Rx Dental & Vision Insurance

• Personal and Family Sick Time & Company Paid Holidays

• Parental Leave

• 401(k) Retirement Plan

• Group Term Life and Travel Assistance

• Voluntary Life and AD&D Insurance

• Health Savings Account Health Care & Dependent Care Flexible Spending Accounts

• Transit and Parking Commuter Benefits

• Short-Term & Long-Term Disability

• Tuition Reimbursement Personal Development Certifications & Learning Opportunities

• Employee Referral Program

• Corporate Sponsored Events & Community Outreach

• annual membership

• Employee Assistance Program

• Supplemental Benefits via Corestream (Critical Care Hospital Indemnity Accident Insurance Legal Assistance and ID theft protection etc.)

• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity EmployerProtected Veterans Individuals with Disabilities or any other basis protected by law ordinance or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities or to apply for a position and you require an accommodation please contact Guidehouse Recruiting at 1- or via email at . All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @ or . Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

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Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.