Analytical Development Synthetic Molecules Characterization Scientist

About the role:

The Scientist Analytical Development Synthetic Molecules Characterizationis responsible forleading scientific and technical work within Analytical Development with a strong focus on the characterization of synthetic molecules including peptides andPROTACs. In this role you will support the transition of novel compounds from Discovery into Development and into first-in-human clinical studies. You will also contribute to ongoing research across the development lifecycle with emphasis on salt and polymorph screening solid-state analytics and analytical method development for Drug Substance and Drug Product.

How you will contribute:

• Independently design plan and execute studies to define the physicochemical properties and behavior of new development candidates that support lead candidate selection and downstream Chemistry Manufacturing and Controls development.
• Lead and contribute to solid-state screening activities including salt and polymorph.
• Drive physicochemical profiling efforts and analytical method development for Drug Substance and Drug Product.
• Develop fit-for-purpose chromatographic methods for analysis.
• Work closely with colleagues in Discovery Drug Safety Drug Metabolism and Pharmacokinetics Process Chemistry Formulation Development and Late Phase Analytical Development to support project goals.
• Provide technical leadership within projects and support strategy development across projects and functions.
• Serve as a technical expert and mentor for junior team members when needed.
• Integrate scientific and technical work across functions to address project issues and support solutions.
• Plan and implement resolutions to technical problems and support local technical or process initiatives.
• Author technical reports and contribute to regulatory filings.

Education and Experience:

• Bachelors degree in Pharmaceutics analytical chemistry organic chemistry or a related pharmaceutical science with 8 or more years of relevant industry experience; or Masters degree in Pharmaceutics physical organic chemistry analytical chemistry or a related pharmaceutical science with 6 or more years of relevant industry experience; or PhD in a relevant discipline with no minimum industry experience.
• Strong understanding of polymorphism and solid-state screening techniques.
• Strong understanding of solid-state analytical techniques including X-ray powder diffraction differential scanning calorimetry thermogravimetric analysis dynamic vapor sorption microscopy and spectroscopic analysis.
• Strong understanding of analytical method development including high-performance liquid chromatography gas chromatography Karl Fischer and dissolution testing.
• Hands-on experience in multiple analytical techniques along with strong knowledge of analytical theory and proven ability to work in a Good Manufacturing Practice laboratory setting.
• Ability to troubleshoot complex scientific and technical issues identify root causes and implement practical solutions.
• Experience working in highly cross-functional teams and sharing knowledge across groups.
• Strong technical writing skills for internal documents and regulatory support.
• Ability to organize work manage priorities and handle multiple tasks within project timelines.
• Experience working with external vendors and internal resources to support project needs.
• Knowledge of modalities beyond traditional small molecules such aspeptidesandPROTACs and familiarity with in silico predictive tools and modeling is highly valued.

Travel requirement:

• May requireapproximately 5-10% travel.