Senior Scientist (Fixed Term Contract) Oncology Research

At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial thinking big and working together to make the impossible a reality.Werepassionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring bignew ideasto life.

Are you ready to work on one of the most excitingOncologypipelines in industry

AstraZenecas vision in Oncology is to push the boundaries of science to change the practice of medicine transform the lives of patients living with cancer and toultimately eliminatecancer as a cause of death.

We areseekingahighly motivatedSenior Scientistwith deep scientific and technicalexpertisespanning both adaptiveand innateimmune cell biologywitha track recordof scientific excellence to joinImmune Cell Engagers Discoveryteamin Cambridge UKfora12-monthperiod. As a Senior Scientistyou will be a key member of a team focused on supporting immune-oncology projects through the drug discovery process. You will bring your theoretical and practicalexpertisein immunology toestablishassay systems and deliver datasets that will have direct impact onimmune-oncology research projects.

Main Duties and Responsibilities

Working in this laboratory-based position within the Immune Cell Engagers Discoverygroupyou will develop design conduct and analysein-vitroand/orex-vivoexperiments to assess the function of our candidate drugs and helpusto dissect the mechanism of action of novel therapeutics targeting the immune system for cancer therapy. You will also review emerging literature and internal data to help inidentifyingnew potential targets and contribute to target validation activities.

A strong foundationin immunology / immuno-oncology andan in-depthtechnicalexpertisefor the analysis of immune function and phenotype is essential for this role. As a highlyorganisedandself-motivated individual with a strong lab/practical background you will stay up to date with relevant technical and intellectual scientificexpertisein tumour immunology and have a genuine passion for this field of research!

Essential Requirements

• A PhD or equivalent experience in immunology/Immuno-oncology/cancer biology.

• Extensive background in immunology and/orimmuno-oncology.

• Experience of a range ofin-vitroandex-vivotechnicalskills for the analysis of human immune cell functionsviamultiparameter flow cytometry ELISA/multiplex assaysELISPOTprimary immune cellisolation andco-culturescell killing assays(likeTDCC ADCC CDC ADCP)TILsisolation andphenotyping.

• Molecularbiology skills includinggene expression analysis and stable cell line generation.

• Working experience with immune cellassaysand/orcharacterization is highly desirable.

• Strong interpersonal influencing negotiating and collaboration skills together with evidence of having used theseskillsto support problem solving andindelivering theprojects ina collaborative environment.

• Depth of understanding andstrongenthusiasm for immunology and immuno-oncology.

• Proventrack recordofscientific accomplishmentsasevidentfrom publications/patents.

• Data processing statisticalanalysisand interpretation.

• Experienceinpreparing written scientific reports (e.g.manuscripts) and oral presentations (e.g.slides posters).

• Ability to record protocols and experimentsin a timely mannerandmaintainan excellent electronicnotebook(eLNB).

Desirable Requirements

• We encourage applications from candidates who haveexperience in the evaluation of immunecellfunctionsandindevelopingand deployingcomplex immunological assaysto understand the MOA of novel therapeutics.

• Expertisein fieldsof T-cell engagersT cell exhaustion tumour myeloid and/or NK biology.

• Experienceinvisualizing/quantifyinghigh content multi-parameter flowcytometrydata/transcriptomic datasets.

• Candidates who candemonstrateproficiencyinleveragingAI technologies including machine learning data analysis and algorithm development to enhance research outcomes alongside strongproblem solvingskills to enable integration of these tools into scientific workflows are strongly preferred.

• Prior experience with spectral flow cytometry.

• Working experience with 3Dcell culture.

• Experienceinworking with patient-derived tumours/TILs

• Knowledge of the drug discovery process.

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing -person working gives us the platform we need to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca:
Here scientific rigor meets real-world impact. You will collaborate with inquisitive colleagues academic partners and biotech innovators to tackle complex disease biology supported by leading technologies in data science and AI. We combine ambition with kindness encouraging bold ideas while learning fast from both successes and setbacks. By contributing your experiments and insights you help convert biology into therapies at speedadvancing a pipeline designed to reach more patients across more indications with purpose and care.

Call to Action:
Take this chance to amplify your science and see your work shape the next wave of medicinesjoin us to turn high-quality experiments into life-changing progress for patients.