Senior Director, Statistical Innovation

Title:

Senior Director Statistical Innovation

Company:

Ipsen Biopharm Ltd

About Ipsen:

Ipsen is a mid-sized global biopharmaceutical company with a focus on transformative medicines in three therapeutic areas: Oncology Rare Disease and Neuroscience. Supported by nearly 100 years of development experience with global hubs in the U.S. France and the U.K we tackle areas of high unmet medical need through research and innovation.

Our passionate teams in more than 40 countries are focused on what matters and endeavor every day to bring medicines to patients in 88 countries. We build a workplace that champions human-centric leadership and fosters a culture of collaboration excellence and impact. At Ipsen every individual is empowered to be their true selves grow and thrive alongside the companys success. Join us on our journey towards sustainable growth creating real impact on patients and society!

For more information visit us at follow our latest news on LinkedIn and Instagram.

Job Description:

WHAT - Summary & Purpose of the Position

The Senior Director Statistical Innovation leads innovative methodology advanced modelling and data-driven decision support across Ipsens R&D portfolio strengthening development strategy through design simulation and predictive analytics.

The role leads a specialist team of 3 to 5 quantitative experts supporting innovative trial design advanced modelling digital twins virtual controls patient journey modelling and data mining to improve development decisions study efficiency population selection and portfolio value.

Working closely with Clinical Development Biostatistics Statistical Programming Translational Medicine Biomarkers Regulatory Affairs Data Science Business Development Asset Teams and Biometry Leadership the role ensures innovative statistical approaches are scientifically rigorous operationally feasible and aligned with regulatory clinical and portfolio decision needs.

The role builds a sustainable statistical innovation capability through high-value use cases standards reusable tools external engagement specialist talent development and broader Biometry and asset-team upskilling.

WHAT - Main Responsibilities & Technical Competencies

Lead Statistical Innovation within Biometry accountable for strategy priorities quality and capability building across a 3 to 5 person specialist team.

Provide strategic input to innovative trial designs including adaptive Bayesian enrichment external-control master protocol interim simulation and endpoint strategies.

Develop simulation frameworks to assess operating characteristics optimize sample size test decision rules and support go/no-go decisions.

Lead advanced modelling across clinical development and evidence generation including disease progression dose/regimen patient journeys digital twins virtual controls.

Drive data mining and predictive modelling to identify response predictors heterogeneity enrichment opportunities prognostic factors and patient subgroups.

Advise on external controls digital twins Bayesian borrowing historical data and RWE addressing bias confounding estimands data quality regulatory acceptability and interpretability.

Identify and implement emerging statistical and modelling approaches for high-impact Ipsen use cases.

Establish standards reusable code templates documentation QC expectations and governance for innovation deliverables.

Lead and develop statisticians through prioritization coaching recruitment input and succession planning.

Work with Biostatistics and Statistical Programming to ensure methods are feasible robust reproducible and submission-ready.

Represent Biometry in governance asset reviews development planning due diligence and external scientific discussions.

Build external networks with academics consortia and industry groups to maintain methodological currency.

Communicate complex statistical and modelling outputs clearly to support senior decisions development strategy and portfolio prioritization.

HOW - Behavioural Competencies Required

Competency Competency Behavioural Markers Explanation of Choice

Ensures Accountability

Ensures single accountable referents per task/project/outcome (independent of organizational context or multi-team projects)

Builds and anchors an environment where people have the skills and habits to ask for clarification when accountabilities are unclear

Consults/seeks relevant stakeholder views/expertise and coaches/ensures decisions are made by consent vs. consensus

Takes personal accountability for decisions actions successes and failures and fosters the same for others

Follows through on commitment and makes sure others do the same

Owns innovation strategy methodology quality priorities and decision-ready outputs.

Develops/Coaches Talent

Able to identify and align career goals and blend organizational objectives into a cohesive development plan for self and team

Able to coach

Provides structured actionable regular and directional feedback and acts as a coach to empower people to own their own growth/development

Prepares their own succession plans

Displays a radically human-centered mindset; puts people first; focuses on doing good

Demonstrates ability to build team effectiveness

Leads a specialist team and builds broader Biometry and asset-team capability.

Drive Vision and Strategy

Paints a compelling picture of the vision (future status quo) and strategy that motivates others to action Sets direction for innovation modelling digital twins and analytics to increase PTRS and portfolio value.

Manage Complexity

Identifies contradictory information/demands/inputs to effectively solve problems

Develops and evaluates alternative scenario and solutions

Able to identify what truly matters and ruthlessly focus/ prioritize on making decisions with real impact Navigates complex scientific regulatory data modelling and operational decisions.

Communicates Effectively

Asks open questions and digs deeper; shows care and respect for different perspectives (both verbally and non-verbally) and able to relate to other points of view

Communicates transparently tells it how it is while keeping the communication respectful

Builds clear and crisp messages with structure and focus uses visual communication and storytelling to make the message easy to digest and connect with the outcomes

Demonstrates gravitas

Turns complex quantitative concepts into clear recommendations for teams leaders and stakeholders.

HOW - Knowledge & Experience

Knowledge & Experience (essential):

10 years of pharmaceutical biotechnology CRO academic or related quantitative experience with a PhD or equivalent experience with an MS/MSc.

Deep expertise in innovative trial design advanced modelling simulation predictive analytics and data mining to support evidence generation and key clinical development population dose/regimen endpoint and portfolio decisions.

Strong understanding of clinical development regulatory expectations estimands missing data multiplicity bias and confounding.

Experience leading specialist quantitative teams including prioritization coaching capability development delivery oversight stakeholder management and succession planning.

Strong programming capability in R Python SAS or equivalent statistical computing environments with the ability to guide reproducible modelling and simulation workflows.

Proven ability to influence global cross-functional teams and communicate complex methods assumptions uncertainty limitations and decisions clearly.

Knowledge & Experience (preferred):

Experience with advanced data science methods including digital twins virtual/external controls Bayesian borrowing causal inference patient journeys machine learning.

Experience in oncology rare disease neuroscience drug development.

Track record of scientific publications conference presentations external collaborations or contributions to industry working groups in statistical innovation or quantitative methods.

Education / Certifications (essential):

MS/MSc or PhD in statistics mathematics or another relevant quantitative discipline.

Language(s) (essential):

Fluent in English with e

We are committed to creating a workplace where everyone feels heard valued and supported; where we embrace The Real Us. The value we place on different perspectives and experiences drives our commitment to inclusion and equal opportunities. When we include diverse ways of thinking we make more thoughtful decisions and discover more innovative solutions. Together we strive to better understand the communities we serve. This means we also want to help you perform at your best when applying for a role with us. If you require any adjustments or support during the application process please let the recruitment team know. This information will be handled with care and will not affect the outcome of your application.