Early Development Program Lead – Cambridge

At Insmed every moment and every patient counts and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases youll be part of a community that prioritizes the human experience celebrates curiosity and values every persons contributions to meaningful progress. That commitment has earned us recognition as Science magazines No. 1 Top Employer for five consecutive years certification as a Great Place to Work in the U.S. and a place on The Sunday Times Best Places to Work list in the UK.

For patients for each other and for the future of science were in. Are you

About the Role:

What Youll Do:

In this role youll have the opportunity to serve as the primary bridge between the Cambridge Research organization and Insmeds Development functions; lead and coordinate cross-functional early development project teams spanning medicinal chemistry CMC formulation biology toxicology DMPK/ADME translational science regulatory clinical and patient advocacy. Youll also:

Project Leadership

• Provide strategicscientific projectleadership and oversight for the cross-functionalteamto spearhead the definition ofprojectobjectives.

• Lead the definition and oversee execution of the scientific strategy for assigned small molecule and/or ASO programs from late lead optimization up to IND.

• Establish productive working relationships with CROs and CDMOs to ensure timely completion of outsourced activities partnering with relevant Insmed functions to identify assess and oversee.

• Integrate multi-disciplinary data to drive candidate selection decisions aligned with the Target Product Profile (TPP).

• Facilitate resource allocation and decision-making across functions with competing priorities and timelines.

• Set ambition and define & drive project strategy through key milestones; accountable forprojecttimeline and execution tofacilitatemeeting deliverablesnecessary for project continuation.

• Lead identification and management of key risks across scientific CMC and clinical domains includingappropriate mitigationand contingency planning.

Project Management

• Work with Program Management to develop maintain and communicate integrated project plans timelines budgets and risk registers.

• Lead cross functional discussions to develop early TPPs.

• Facilitate team meetings drive decision-making and ensure accountability across functions; prepare and present program updates to senior leadership and governance committees.

• Proactively identify and communicate risks and develop mitigation strategies to keep programs on track.

• Collaborate with portfolio management to ensure alignment with corporate strategy.

• Oversee provision of updates to the Cambridge Development Program team to ensure timely awareness of approaching project needs and approaching development milestones.

Communication & Reporting

• Author and review key program documents including early TPPs project charters integrated development plans and support of any regulatory briefing documents; present program status and support presentations of scientific findings to internal leadership.

Who You Are:

You must have a PhD in Medicinal Chemistry Pharmacology Pharmaceutical Sciences Translational Medicine Biochemistry or a related discipline with direct relevance to small molecule or oligonucleotide drug discovery and development. Additionally you have:

• 15years of experience in the pharmaceutical/biotech industry with demonstration of increasing levels of responsibility.

• 5 years of industry experience in small molecule drug and/or oligonucleotide therapeutic discovery and development.

• Demonstrated experience leading cross-functional drug development matrix teams in a pharmaceutical or biotech environment.

• A track record of advancing programs from lead optimization through IND and into FIH.

• Experience engaging with regulatory agencies (FDA EMA) in early development settings (e.g. pre-IND meetings; INTERACT meetings) and Type B/C meetings.

• Highly effective and proactive communication skills with the ability to manage in a matrix environment by influence.

• Proficiency in building trust inspiring confidence clearly articulating challenges and opportunities and bringing teams into alignment across complex decision making.

Where Youll Work

This is a fully remote role. It can be performed effectively from anywhere while staying connected to yourInsmedteam and travel for team meetings or eventswillbe expected.

Travel Requirements

This position involves occasional domestic and/or international travel (approximately 10%).

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Life at Insmed

At Insmed youll find a culture as human as our missionintentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day with support for how you work how you grow and how you show up for patients your team and yourself.

Our offerings include:

• Flexible work schedules with purposeful in-person collaboration

• Competitive retirement benefits global equity awards and participation in our Employee Stock Purchase Plan (ESPP)

• Career development through the Insmed Learning Institute external programs LinkedIn Learning and role-specific training

• AI-powered and on-demand learning tools including a digital assistant to help navigate internal resources

• Hybrid-friendly technology and IT support for seamless teamwork across locations and time zones

• Global recognition programs and Employee Resource Groups

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.

Current Insmed Employees: Please apply via the Jobs Hub in Workday.

Insmed Incorporated is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex gender identity sexual orientation race color religion national origin disability age or any other characteristic protected by law.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

Insmed is committed to providing access equal opportunity and reasonable accommodation for individuals with disabilities in employment its services programs and activities. To request reasonable accommodation to participate in the job application or interview process please contact us by email at and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.