Research Associate In Cellular Assay Development

At Roche you can show up as yourself embraced for the unique qualities you bring. Our culture encourages personal expression open dialogue and genuine connections where you are valued accepted and respected for who you are allowing you to thrive both personally and professionally. This is how we aim to prevent stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche where every voice matters.

In Roches Pharmaceutical Research and Early Development organization (pRED) we make transformative medicines for patients in order to tackle some of the worlds toughest unmet healthcare needs. At pRED we are united by our mission to transform science into medicines. Together we create a culture defined by curiosity responsibility and humility where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

Therapeutic Modalities (TMo) organization accountable for translating disease biology into high-quality drug candidates across small molecules large molecules oligonucleotides and genomic medicines. By integrating deep modality expertise with cross-disciplinary collaboration TMo drives innovation within and across platforms to enable differentiated sustainable therapeutic impact.

Joining Small Molecule Research Discovery within Therapeutic Modalities you will work within a highly engaged cross-functional team bridging cell biology automation and multiple therapeutic this role you drive innovation through strong commitment to lab science by developing the foundational cellular models that power our drug discovery pipeline.

Your key responsibilities include:

• Developing optimizing and validating robust cell-based functional assaysincluding complex 3D modelsusing technologies such as HTRF AlphaLISA Luminescence and High-Content Imaging.

• Miniaturizing cellular assays into high-density plate formats (384-well and 1536-well plates) optimizing performance parameters such as Z-factor and signal-to-background ratio.

• Maintaining characterizing and performing quality control on a wide range of mammalian cell lines including primary cells continuous lines and induced pluripotent stem cells (iPSCs).

• Partnering closely with the High-Throughput Screening and Profiling team to seamlessly transfer new assays onto integrated robotic systems.

• Running routine cellular assays to generate high-quality data supporting structure-activity relationship (SAR) studies for portfolio projects.

• Analyzing complex screening datasets using modern scientific tools (e.g. Genedata Screener Spotfire) and documenting workflows meticulously in Electronic Lab Notebooks (ELN).

• Serving as the primary cellular assay expert on multidisciplinary project teams sharing insights across chemistry High-Throughput Screening and Profiling and therapeutic area groups.

You are a curious highly motivated scientist who thrives on solving complex biological challenges. You bring a collaborative mindset value diverse perspectives and are eager to apply your expertise to discover life-changing treatments.

Qualifications and skills:

• Masters degree in Cell Biology Molecular Biology or a closely related scientific discipline.

• 5 years of relevant industry research experience focused on advanced cell culture and cell-based assay development.

• Demonstrated experience in miniaturizing assay workflows into 384- and 1536-well plate formats and utilizing automated liquid-handling systems.

• Strong proficiency in data analysis statistical evaluation and presenting scientific findings clearly to multidisciplinary teams.

• Fluency in English with strong interpersonal and communication skills.

• Flexibility and a resourceful problem-solving approach tailored to a dynamic lab environment.

• Nice to have: Hands-on experience with iPSC differentiation 3D cellular models or Design-of-Experiments (DoE) methodology.

How to Apply

Ready to join our team Please submit the following documents: Updated CV Cover Letter Copy of your Higher Education Diploma

Please be advised that this position is 100% lab-based.

A healthier future drives us to innovate. Together more than 100000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities foster creativity and keep our ambitions high so we can deliver life-changing healthcare solutions that make a global impact.

Lets build a healthier future together.

Roche is an Equal Opportunity Employer.